26-30

EFFECT OF 2-HYDROXYPROPYL- β -CYCLODEXTRIN ON SOLUBILITY OF NOVEL CYTOTOXIC COMPOUNDS

Complexation processes in the systems of 2-hydroxylpropyl-β-cyclodextrin − cytotox-ic substances within the temperature range of 293 – 315 К were studied by the UV-spectroscopy method. It was proved that complexation leads to the formation of supramolec-ular inclusion compounds with 1:1 component ratio. Stability constants of the complexes and thermodynamic parameters of the formation of the inclusion compound 2-hydroxylpropyl-β-cyclodextrin – tris(1-pentyl-1Н-indol-3-yl)methanol were calculated. The obtained complex of 2-hydroxylpropyl-β-cyclodextrin – tris(1-pentyl-1Н-indol-3-yl) methylium chloride was found to be unstable.

Key words: inclusion complexes, 2-hydroxypropyl-β-cyclodextrin, cytotoxicity, stability con-stant, thermodynamics

2016, Т. 59, № 3, Стр. 26-30