Parfenyuk E.V.

EFFECT OF pH ON ADSORPTION KINETICS OF ANTICOAGULANT WARFARIN ON MESOPOROUS SILICA MATERIALS

Synthesis and study of drug composites based on porous silica is promising area for development of new drug formulations with improved pharmacological and consumer prop-erties. Adsorption is one of easiest and fruitful preparation method of drug composites with porous materials. To develop conditions of preparation of novel silica composites with anti-coagulant warfarin by adsorption, the influence of medium pH on kinetics of warfarin ad-sorption on mesoporous silica materials with different surface chemistry was studied. For this purpose unmodified mesoporous silica was synthesized by sol-gel method. The phenyl and mercaptopropyl modified silica materials were prepared by grafting. The results of ki-netic study showed that the warfarin adsorption predominantly follows the pseudo-second-order kinetics. The rate constants of the pseudo-second-order (k2) were found to be depend-ent on pH and presence of the organic surface groups.

2016, Т. 59, № 6, Стр. 58-63
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